Wegovy is a once-weekly injectable medication containing semaglutide that supports weight loss when combined with diet and exercise. Proper dosing begins at a low level and increases gradually to minimize side effects while reaching the maintenance dose. This guide explains the standard escalation approach, notes earlier reference points, and provides concrete steps for following the schedule correctly.
Wegovy Dosing Guidelines 2017
Early clinical research on semaglutide for weight management established the principle of slow titration to improve tolerability. Dosing started at 0.25 mg weekly for four weeks before any increase. Subsequent steps raised the dose by 0.5 mg or 1 mg increments every four weeks until reaching 2.4 mg. These foundational concepts shaped later protocols even though formal approval occurred years afterward.
Wegovy Dosing Guidelines
Current guidelines follow a four-week escalation pattern:
- Weeks 1–4: 0.25 mg
- Weeks 5–8: 0.5 mg
- Weeks 9–12: 1 mg
- Weeks 13–16: 1.7 mg
- Week 17 onward: 2.4 mg maintenance
Injections are given on the same day each week, with or without food. Missed doses should be taken within five days; otherwise the next scheduled dose resumes.
Why It Matters
Following the recommended escalation reduces gastrointestinal discomfort that can occur when doses increase too quickly. Consistent weekly timing supports steady medication levels, which helps sustain appetite regulation and supports long-term weight-management efforts.
How to Administer Wegovy Doses
- Store pens in the refrigerator until first use, then they may stay at room temperature for up to 28 days.
- Choose an injection site on the abdomen, thigh, or upper arm and rotate locations weekly.
- Clean the skin, unlock the pen, and press firmly against the skin until the yellow bar stops moving.
- Dispose of used pens in a sharps container.
- Track each dose date and amount in a simple log to confirm adherence to the schedule.
Dosing Escalation Schedule
| Week Range | Dose (mg) | Purpose |
|---|---|---|
| 1–4 | 0.25 | Initial tolerance building |
| 5–8 | 0.5 | First increase |
| 9–12 | 1.0 | Continued escalation |
| 13–16 | 1.7 | Final step before maintenance |
| 17+ | 2.4 | Maintenance dose |
FAQ
What happens if a dose is missed?
Take the missed dose as soon as possible if fewer than five days have passed since the scheduled day. If more than five days have elapsed, skip it and resume on the next planned injection day without doubling the dose.
Can the dose be adjusted without medical supervision?
Dose changes should only occur under guidance from a healthcare provider. Self-adjustment can increase side-effect risk or reduce effectiveness of the weight-management plan.
Last updated: September 16, 2026